Captopril vs Sitagliptin

## Captopril vs Sitagliptin: Overview

This comparison examines the pharmacological differences between **Captopril** and **Sitagliptin**.

## Mechanism of Action

**Captopril**: First orally active ACE inhibitor; contains thiol group that binds zinc at ACE active site.

**Sitagliptin**: DPP-4 inhibitor increasing incretin levels.

## Pharmacokinetics

**Half-life**: Captopril — 1.9 hours; Sitagliptin — 12.4 hours.

## Chemical Properties

**Molecular Formula**: Captopril — C9H15NO3S; Sitagliptin — C16H15F6N5O.

**Molecular Weight**: Captopril — 217.2850 g/mol; Sitagliptin — 407.3140 g/mol.

**Type**: Captopril — Small molecule; Sitagliptin — Small molecule.