Dapagliflozin vs Hydrochlorothiazide

## Dapagliflozin vs Hydrochlorothiazide: Overview

This comparison examines the pharmacological differences between **Dapagliflozin** and **Hydrochlorothiazide**.

## Mechanism of Action

**Dapagliflozin**: Selective SGLT2 inhibitor reducing renal glucose and sodium reabsorption.

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

## Pharmacokinetics

**Half-life**: Dapagliflozin — 12.9 hours; Hydrochlorothiazide — 6-15 hours.

## Chemical Properties

**Molecular Formula**: Dapagliflozin — C21H25ClO6; Hydrochlorothiazide — C7H8ClN3O4S2.

**Molecular Weight**: Dapagliflozin — 408.8730 g/mol; Hydrochlorothiazide — 297.7400 g/mol.

**Type**: Dapagliflozin — Small molecule; Hydrochlorothiazide — Small molecule.