Diphenhydramine vs Ibuprofen

## Diphenhydramine vs Ibuprofen: Overview

This comparison examines the pharmacological differences between **Diphenhydramine** and **Ibuprofen**.

## Mechanism of Action

**Diphenhydramine**: First-generation H1 antihistamine with anticholinergic properties.

**Ibuprofen**: Non-selective COX inhibitor reducing prostaglandin synthesis.

## Pharmacokinetics

**Half-life**: Diphenhydramine — 2-8 hours; Ibuprofen — 2-4 hours.

## Chemical Properties

**Molecular Formula**: Diphenhydramine — C17H21NO; Ibuprofen — C13H18O2.

**Molecular Weight**: Diphenhydramine — 255.3550 g/mol; Ibuprofen — 206.2810 g/mol.

**Type**: Diphenhydramine — Small molecule; Ibuprofen — Small molecule.