Diphenhydramine vs Sumatriptan

## Diphenhydramine vs Sumatriptan: Overview

This comparison examines the pharmacological differences between **Diphenhydramine** and **Sumatriptan**.

## Mechanism of Action

**Diphenhydramine**: First-generation H1 antihistamine with anticholinergic properties.

**Sumatriptan**: Selective 5-HT1B/1D receptor agonist.

## Pharmacokinetics

**Half-life**: Diphenhydramine — 2-8 hours; Sumatriptan — 2.5 hours.

## Chemical Properties

**Molecular Formula**: Diphenhydramine — C17H21NO; Sumatriptan — C14H21N3O2S.

**Molecular Weight**: Diphenhydramine — 255.3550 g/mol; Sumatriptan — 295.4020 g/mol.

**Type**: Diphenhydramine — Small molecule; Sumatriptan — Small molecule.