Duloxetine vs Pregabalin

## Duloxetine vs Pregabalin: Overview

This comparison examines the pharmacological differences between **Duloxetine** and **Pregabalin**.

## Mechanism of Action

**Duloxetine**: Serotonin-norepinephrine reuptake inhibitor (SNRI).

**Pregabalin**: Binds alpha-2-delta subunit of voltage-gated calcium channels.

## Pharmacokinetics

**Half-life**: Duloxetine — 12 hours; Pregabalin — 6.3 hours.

## Chemical Properties

**Molecular Formula**: Duloxetine — C18H19NOS; Pregabalin — C8H17NO2.

**Molecular Weight**: Duloxetine — 297.4150 g/mol; Pregabalin — 159.2260 g/mol.

**Type**: Duloxetine — Small molecule; Pregabalin — Small molecule.