Hydrochlorothiazide vs Tacrolimus

## Hydrochlorothiazide vs Tacrolimus: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Tacrolimus**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Tacrolimus**: Calcineurin inhibitor binding FKBP12; suppresses IL-2 transcription.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Tacrolimus — 12 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Tacrolimus — C44H69NO12.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Tacrolimus — 804.0180 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Tacrolimus — Small molecule.