Hydromorphone vs Lorazepam

## Hydromorphone vs Lorazepam: Overview

This comparison examines the pharmacological differences between **Hydromorphone** and **Lorazepam**.

## Mechanism of Action

**Hydromorphone**: Semisynthetic mu-opioid receptor agonist approximately 5 times more potent than morphine.

**Lorazepam**: Intermediate-acting benzodiazepine enhancing GABA-A receptor chloride conductance.

## Pharmacokinetics

**Half-life**: Hydromorphone — 2-3 hours; Lorazepam — 10-20 hours.

## Chemical Properties

**Molecular Formula**: Hydromorphone — C17H19NO3; Lorazepam — C15H10Cl2N2O2.

**Molecular Weight**: Hydromorphone — 285.3380 g/mol; Lorazepam — 321.1580 g/mol.

**Type**: Hydromorphone — Small molecule; Lorazepam — Small molecule.