Loratadine vs Trazodone

## Loratadine vs Trazodone: Overview

This comparison examines the pharmacological differences between **Loratadine** and **Trazodone**.

## Mechanism of Action

**Loratadine**: Second-generation H1 antihistamine with minimal CNS effects.

**Trazodone**: Serotonin antagonist and reuptake inhibitor (SARI).

## Pharmacokinetics

**Half-life**: Loratadine — 8 hours; Trazodone — 5-9 hours.

## Chemical Properties

**Molecular Formula**: Loratadine — C22H23ClN2O2; Trazodone — C19H22ClN5O.

**Molecular Weight**: Loratadine — 382.8800 g/mol; Trazodone — 371.8640 g/mol.

**Type**: Loratadine — Small molecule; Trazodone — Small molecule.