Lovastatin vs Rosuvastatin

## Lovastatin vs Rosuvastatin: Overview

This comparison examines the pharmacological differences between **Lovastatin** and **Rosuvastatin**.

## Mechanism of Action

**Lovastatin**: First naturally derived statin; prodrug hydrolyzed to active beta-hydroxy acid inhibiting HMG-CoA reductase.

**Rosuvastatin**: Competitive inhibitor of HMG-CoA reductase.

## Pharmacokinetics

**Half-life**: Lovastatin — 2-3 hours; Rosuvastatin — 19 hours.

## Chemical Properties

**Molecular Formula**: Lovastatin — C24H36O5; Rosuvastatin — C22H28FN3O6S.

**Molecular Weight**: Lovastatin — 404.5390 g/mol; Rosuvastatin — 481.5390 g/mol.

**Type**: Lovastatin — Small molecule; Rosuvastatin — Small molecule.