Metronidazole vs Trimethoprim

## Metronidazole vs Trimethoprim: Overview

This comparison examines the pharmacological differences between **Metronidazole** and **Trimethoprim**.

## Mechanism of Action

**Metronidazole**: Forms cytotoxic free radicals that damage bacterial DNA.

**Trimethoprim**: Dihydrofolate reductase inhibitor (bacterial selective).

## Pharmacokinetics

**Half-life**: Metronidazole — 8 hours; Trimethoprim — 8-10 hours.

## Chemical Properties

**Molecular Formula**: Metronidazole — C6H9N3O3; Trimethoprim — C14H18N4O3.

**Molecular Weight**: Metronidazole — 171.1540 g/mol; Trimethoprim — 290.3180 g/mol.

**Type**: Metronidazole — Small molecule; Trimethoprim — Small molecule.