Paroxetine vs Sertraline

## Paroxetine vs Sertraline: Overview

This comparison examines the pharmacological differences between **Paroxetine** and **Sertraline**.

## Mechanism of Action

**Paroxetine**: Potent selective serotonin reuptake inhibitor with additional muscarinic and NE reuptake inhibition.

**Sertraline**: Selective serotonin reuptake inhibitor (SSRI).

## Pharmacokinetics

**Half-life**: Paroxetine — 21 hours; Sertraline — 26 hours.

## Chemical Properties

**Molecular Formula**: Paroxetine — C19H20FNO3; Sertraline — C17H17Cl2N.

**Molecular Weight**: Paroxetine — 329.3730 g/mol; Sertraline — 306.2290 g/mol.

**Type**: Paroxetine — Small molecule; Sertraline — Small molecule.