Phenytoin vs Tofacitinib

## Phenytoin vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Phenytoin** and **Tofacitinib**.

## Mechanism of Action

**Phenytoin**: Sodium channel blocker stabilizing inactive state.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Phenytoin — 22 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Phenytoin — C15H12N2O2; Tofacitinib — C16H20N6O.

**Molecular Weight**: Phenytoin — 252.2680 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Phenytoin — Small molecule; Tofacitinib — Small molecule.