Rituximab vs Trastuzumab

## Rituximab vs Trastuzumab: Overview

This comparison examines the pharmacological differences between **Rituximab** and **Trastuzumab**.

## Mechanism of Action

**Rituximab**: Chimeric anti-CD20 IgG1 monoclonal antibody inducing B-cell depletion via CDC, ADCC, and apoptosis.

**Trastuzumab**: Anti-HER2 monoclonal antibody inhibiting receptor signaling.

## Pharmacokinetics

**Half-life**: Rituximab — 22 days; Trastuzumab — 28 days.

## Chemical Properties

**Type**: Rituximab — Antibody; Trastuzumab — Antibody.