Simvastatin vs Spironolactone

## Simvastatin vs Spironolactone: Overview

This comparison examines the pharmacological differences between **Simvastatin** and **Spironolactone**.

## Mechanism of Action

**Simvastatin**: Prodrug converted to active form that inhibits HMG-CoA reductase.

**Spironolactone**: Mineralocorticoid receptor antagonist.

## Pharmacokinetics

**Half-life**: Simvastatin — 2 hours; Spironolactone — 1.4 hours.

## Chemical Properties

**Molecular Formula**: Simvastatin — C25H38O5; Spironolactone — C24H32O4S.

**Molecular Weight**: Simvastatin — 418.5700 g/mol; Spironolactone — 416.5740 g/mol.

**Type**: Simvastatin — Small molecule; Spironolactone — Small molecule.