Sitagliptin vs Tofacitinib

## Sitagliptin vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Sitagliptin** and **Tofacitinib**.

## Mechanism of Action

**Sitagliptin**: DPP-4 inhibitor increasing incretin levels.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Sitagliptin — 12.4 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Sitagliptin — C16H15F6N5O; Tofacitinib — C16H20N6O.

**Molecular Weight**: Sitagliptin — 407.3140 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Sitagliptin — Small molecule; Tofacitinib — Small molecule.