Spironolactone vs Tofacitinib

## Spironolactone vs Tofacitinib: Overview

This comparison examines the pharmacological differences between **Spironolactone** and **Tofacitinib**.

## Mechanism of Action

**Spironolactone**: Mineralocorticoid receptor antagonist.

**Tofacitinib**: Pan-JAK inhibitor with preference for JAK1 and JAK3 blocking pro-inflammatory cytokine signaling.

## Pharmacokinetics

**Half-life**: Spironolactone — 1.4 hours; Tofacitinib — 3.2 hours.

## Chemical Properties

**Molecular Formula**: Spironolactone — C24H32O4S; Tofacitinib — C16H20N6O.

**Molecular Weight**: Spironolactone — 416.5740 g/mol; Tofacitinib — 312.3700 g/mol.

**Type**: Spironolactone — Small molecule; Tofacitinib — Small molecule.