Spironolactone vs Trimethoprim

## Spironolactone vs Trimethoprim: Overview

This comparison examines the pharmacological differences between **Spironolactone** and **Trimethoprim**.

## Mechanism of Action

**Spironolactone**: Mineralocorticoid receptor antagonist.

**Trimethoprim**: Dihydrofolate reductase inhibitor (bacterial selective).

## Pharmacokinetics

**Half-life**: Spironolactone — 1.4 hours; Trimethoprim — 8-10 hours.

## Chemical Properties

**Molecular Formula**: Spironolactone — C24H32O4S; Trimethoprim — C14H18N4O3.

**Molecular Weight**: Spironolactone — 416.5740 g/mol; Trimethoprim — 290.3180 g/mol.

**Type**: Spironolactone — Small molecule; Trimethoprim — Small molecule.