Spironolactone vs Upadacitinib

## Spironolactone vs Upadacitinib: Overview

This comparison examines the pharmacological differences between **Spironolactone** and **Upadacitinib**.

## Mechanism of Action

**Spironolactone**: Mineralocorticoid receptor antagonist.

**Upadacitinib**: Selective JAK1 inhibitor reducing signaling from cytokines implicated in autoimmune diseases.

## Pharmacokinetics

**Half-life**: Spironolactone — 1.4 hours; Upadacitinib — 9-14 hours.

## Chemical Properties

**Molecular Formula**: Spironolactone — C24H32O4S; Upadacitinib — C17H19F3N6O.

**Molecular Weight**: Spironolactone — 416.5740 g/mol; Upadacitinib — 380.3700 g/mol.

**Type**: Spironolactone — Small molecule; Upadacitinib — Small molecule.