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Acetohexamide

CHEMBL1589 Phase 4 अनुमोदित Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
324.4 g/mol
LogP
2.4
Phase
4

An older oral diabetes medication belonging to the sulfonylurea class that stimulates the pancreas to release more insulin after meals. It was used to lower blood glucose in people with type 2 diabetes whose pancreas still produces some insulin. It has largely been replaced by newer sulfonylureas and other diabetes medications with more favorable safety profiles and less risk of prolonged low blood sugar.

आणविक भार

324.4000 g/mol

LogP

2.40

TPSA

101.00 Ų

लिपिंस्की RO5

उत्तीर्ण

चिकित्सीय क्षेत्र

Type 2 Diabetes Cardiovascular Disease

क्रिया का तंत्र

Binds to the sulfonylurea receptor (SUR1) on pancreatic beta cells, closing ATP-sensitive potassium channels and triggering membrane depolarization. This opens voltage-gated calcium channels, leading to insulin exocytosis.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

तंत्र

Binds to the sulfonylurea receptor (SUR1) on pancreatic beta cells, closing ATP-sensitive potassium channels and triggering membrane depolarization. This opens voltage-gated calcium channels, leading to insulin exocytosis.

2D संरचना

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(=O)c1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)

                

                

                

                    
                    

                        
Molecular Formula

                        
C15H20N2O4S

                    

                    
                    

                        
HBD / HBA

                        
2 / 4

                    

                    
                    

                        
घूर्णनीय बंधन

                        
4

                    

                    
                    
                    

                        
भारी परमाणु

                        
22

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
अक्सर पूछे जाने वाले प्रश्न

                

                    
                    

                        
                        

                            
An older oral diabetes medication belonging to the sulfonylurea class that stimulates the pancreas to release more insulin after meals. It was used to lower blood glucose in people with type 2 diabetes whose pancreas still produces some insulin. It has largely been replaced by newer sulfonylureas and other diabetes medications with more favorable safety profiles and less risk of prolonged low blood sugar.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Binds to the sulfonylurea receptor (SUR1) on pancreatic beta cells, closing ATP-sensitive potassium channels and triggering membrane depolarization. This opens voltage-gated calcium channels, leading to insulin exocytosis.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Acetohexamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1589.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 1989.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
चिकित्सा अस्वीकरण

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.