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Alogliptin

CHEMBL376359 Phase 4 अनुमोदित Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
339.4 g/mol
LogP
0.6
Phase
4

A DPP-4 inhibitor that enhances the body's natural incretin hormones to stimulate insulin secretion and reduce glucagon release in response to meals, lowering blood sugar in adults with type 2 diabetes. It has cardiovascular safety data showing it does not increase the risk of heart failure.

आणविक भार

339.4000 g/mol

LogP

0.60

TPSA

93.70 Ų

लिपिंस्की RO5

उत्तीर्ण

चिकित्सीय क्षेत्र

टाइप 2 मधुमेह मोटापा स्ट्रोक हृदय विफलता हृदय-संवहनी रोग

क्रिया का तंत्र

Inhibits dipeptidyl peptidase-4, the enzyme that rapidly degrades incretin hormones (GLP-1 and GIP). This prolongs incretin activity, stimulating glucose-dependent insulin secretion and suppressing glucagon release.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

तंत्र

Inhibits dipeptidyl peptidase-4, the enzyme that rapidly degrades incretin hormones (GLP-1 and GIP). This prolongs incretin activity, stimulating glucose-dependent insulin secretion and suppressing glucagon release.

2D संरचना

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O

                

                

                
                

                    
InChI

                    
InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C18H21N5O2

                    

                    
                    

                        
HBD / HBA

                        
1 / 5

                    

                    
                    

                        
घूर्णनीय बंधन

                        
3

                    

                    
                    
                    

                        
भारी परमाणु

                        
25

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
अक्सर पूछे जाने वाले प्रश्न

                

                    
                    

                        
                        

                            
A DPP-4 inhibitor that enhances the body's natural incretin hormones to stimulate insulin secretion and reduce glucagon release in response to meals, lowering blood sugar in adults with type 2 diabetes. It has cardiovascular safety data showing it does not increase the risk of heart failure.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits dipeptidyl peptidase-4, the enzyme that rapidly degrades incretin hormones (GLP-1 and GIP). This prolongs incretin activity, stimulating glucose-dependent insulin secretion and suppressing glucagon release.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Alogliptin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL376359.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 11450633.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
चिकित्सा अस्वीकरण

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.