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Clobutinol

CHEMBL1474889 Phase 4 अनुमोदित Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
255.8 g/mol
LogP
3.2
Phase
4

Withdrawal from the market, rather than current practice, defines the status of clobutinol. The compound acted centrally on the cough centre to suppress cough and was for a period available without prescription in several countries. Reports of serious cardiac rhythm disturbance led to its removal from those markets, and it is no longer in therapeutic use. The case is cited as an example of an over-the-counter antitussive withdrawn on cardiac safety grounds after wide exposure in the general population. Structurally it is a small molecule with the formula C14H22ClNO and a molecular weight near 255.8 g/mol. Its recorded development reached the final clinical phase before the safety signal emerged.

An antitussive medication that was used to suppress coughs by acting on the cough center in the brain. It was once available over the counter in several countries but was withdrawn from markets due to concerns about serious heart rhythm disturbances. It should no longer be used.

आणविक भार

255.7800 g/mol

LogP

3.20

TPSA

23.50 Ų

लिपिंस्की RO5

उत्तीर्ण

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D संरचना

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CC(CN(C)C)C(C)(O)Cc1ccc(Cl)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C14H22ClNO/c1-11(10-16(3)4)14(2,17)9-12-5-7-13(15)8-6-12/h5-8,11,17H,9-10H2,1-4H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C14H22ClNO

                    

                    
                    

                        
HBD / HBA

                        
1 / 2

                    

                    
                    

                        
घूर्णनीय बंधन

                        
5

                    

                    
                    
                    

                        
भारी परमाणु

                        
17

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
अक्सर पूछे जाने वाले प्रश्न

                

                    
                    

                        
                        

                            
An antitussive medication that was used to suppress coughs by acting on the cough center in the brain. It was once available over the counter in several countries but was withdrawn from markets due to concerns about serious heart rhythm disturbances. It should no longer be used.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Clobutinol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1474889.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 26937.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-08-20.




        


        
        
    


    



    
चिकित्सा अस्वीकरण

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.