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Clotrimazole

CHEMBL104 Phase 4 अनुमोदित Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
344.8 g/mol
LogP
5.0
Phase
4

A broad-spectrum azole antifungal that disrupts fungal cell membranes by inhibiting ergosterol synthesis, used to treat athlete's foot, vaginal yeast infections, and oral thrush. It is available as creams, lozenges, and vaginal suppositories.

आणविक भार

344.8000 g/mol

LogP

5.00

TPSA

17.80 Ų

लिपिंस्की RO5

उत्तीर्ण

चिकित्सीय क्षेत्र

HIV/एड्स अग्नाशय कैंसर इंफ्लेमेटरी बाउल डिज़ीज़ एटोपिक डर्मेटाइटिस (एक्जिमा) एंडोमेट्रियोसिस ओवेरियन कैंसर कोलोरेक्टल कैंसर क्रॉनिक किडनी डिज़ीज़ थायरॉइड कैंसर नॉन-स्मॉल सेल लंग कैंसर प्रोस्टेट कैंसर मूत्राशय कैंसर लिम्फोमा ल्यूकेमिया स्तन कैंसर हृदय विफलता

क्रिया का तंत्र

Inhibits the fungal cytochrome P450 enzyme lanosterol 14-alpha-demethylase, blocking ergosterol synthesis essential for fungal cell membrane integrity.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

तंत्र

Inhibits the fungal cytochrome P450 enzyme lanosterol 14-alpha-demethylase, blocking ergosterol synthesis essential for fungal cell membrane integrity.

2D संरचना

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1

                

                

                
                

                    
InChI

                    
InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H17ClN2

                    

                    
                    

                        
HBD / HBA

                        
- / 1

                    

                    
                    

                        
घूर्णनीय बंधन

                        
4

                    

                    
                    
                    

                        
भारी परमाणु

                        
25

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
अक्सर पूछे जाने वाले प्रश्न

                

                    
                    

                        
                        

                            
A broad-spectrum azole antifungal that disrupts fungal cell membranes by inhibiting ergosterol synthesis, used to treat athlete's foot, vaginal yeast infections, and oral thrush. It is available as creams, lozenges, and vaginal suppositories.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits the fungal cytochrome P450 enzyme lanosterol 14-alpha-demethylase, blocking ergosterol synthesis essential for fungal cell membrane integrity.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Clotrimazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL104.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 2812.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
चिकित्सा अस्वीकरण

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.