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Daunorubicin Citrate

CHEMBL1200475 Phase 4 अनुमोदित Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
719.6 g/mol
LogP
—
Phase
4

A citrate salt form of daunorubicin with similar chemotherapy properties to the parent compound, used in the treatment of acute leukemias. Like other anthracyclines, it intercalates into DNA and inhibits topoisomerase II. Cumulative cardiotoxicity remains a major dose-limiting concern.

आणविक भार

719.6000 g/mol

TPSA

318.00 Ų

चिकित्सीय क्षेत्र

HIV/एड्स अग्नाशय कैंसर अल्ज़ाइमर रोग इंफ्लेमेटरी बाउल डिज़ीज़ उच्च रक्तचाप ओवेरियन कैंसर कोलोरेक्टल कैंसर क्रॉनिक ऑब्सट्रक्टिव पल्मोनरी डिज़ीज़ (COPD) क्रॉनिक किडनी डिज़ीज़ गैस्ट्रोइसोफेजियल रिफ्लक्स रोग टाइप 2 मधुमेह थायरॉइड कैंसर दर्द प्रबंधन दीर्घकालिक दर्द नॉन-अल्कोहलिक फैटी लिवर डिज़ीज़ नॉन-स्मॉल सेल लंग कैंसर पार्किंसन रोग प्रोस्टेट कैंसर मूत्राशय कैंसर मेलानोमा लिम्फोमा ल्यूकेमिया श्वसन रोग संक्रामक रोग स्तन कैंसर हाइपरलिपिडेमिया हृदय-संवहनी रोग

क्रिया का तंत्र

Inhibits DNA topoisomerase, preventing the relaxation of supercoiled DNA during replication and transcription. This causes DNA strand breaks and triggers apoptosis in rapidly dividing cells.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

तंत्र

Inhibits DNA topoisomerase, preventing the relaxation of supercoiled DNA during replication and transcription. This causes DNA strand breaks and triggers apoptosis in rapidly dividing cells.

2D संरचना

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1.O=C(O)CC(O)(CC(=O)O)C(=O)O

                

                

                
                

                    
InChI

                    
InChI=1S/C27H29NO10.C6H8O7/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t10-,14-,16-,17-,22+,27-;/m0./s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C33H37NO17

                    

                    
                    

                        
HBD / HBA

                        
9 / 18

                    

                    
                    

                        
घूर्णनीय बंधन

                        
9

                    

                    
                    
                    

                        
भारी परमाणु

                        
51

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
अक्सर पूछे जाने वाले प्रश्न

                

                    
                    

                        
                        

                            
A citrate salt form of daunorubicin with similar chemotherapy properties to the parent compound, used in the treatment of acute leukemias. Like other anthracyclines, it intercalates into DNA and inhibits topoisomerase II. Cumulative cardiotoxicity remains a major dose-limiting concern.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits DNA topoisomerase, preventing the relaxation of supercoiled DNA during replication and transcription. This causes DNA strand breaks and triggers apoptosis in rapidly dividing cells.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Daunorubicin Citrate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1200475.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 9961878.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
चिकित्सा अस्वीकरण

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.