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Decitabine

CHEMBL1201129 Phase 4 अनुमोदित Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
228.2 g/mol
LogP
-1.2
Phase
4

A hypomethylating agent that is incorporated into DNA and inhibits DNA methyltransferase, reactivating silenced tumor suppressor genes; used for myelodysplastic syndromes and acute myeloid leukemia. At low doses it has epigenetic effects distinct from its cytotoxic activity at higher doses.

आणविक भार

228.2100 g/mol

LogP

-1.20

TPSA

121.00 Ų

लिपिंस्की RO5

उत्तीर्ण

चिकित्सीय क्षेत्र

अग्नाशय कैंसर उच्च रक्तचाप ऑस्टियोपोरोसिस ओवेरियन कैंसर कोलोरेक्टल कैंसर थायरॉइड कैंसर नॉन-स्मॉल सेल लंग कैंसर प्रोस्टेट कैंसर मूत्राशय कैंसर मेलानोमा लिम्फोमा ल्यूकेमिया स्तन कैंसर

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D संरचना

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
Nc1ncn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1

                

                

                
                

                    
InChI

                    
InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C8H12N4O4

                    

                    
                    

                        
HBD / HBA

                        
3 / 4

                    

                    
                    

                        
घूर्णनीय बंधन

                        
2

                    

                    
                    
                    

                        
भारी परमाणु

                        
16

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
अक्सर पूछे जाने वाले प्रश्न

                

                    
                    

                        
                        

                            
A hypomethylating agent that is incorporated into DNA and inhibits DNA methyltransferase, reactivating silenced tumor suppressor genes; used for myelodysplastic syndromes and acute myeloid leukemia. At low doses it has epigenetic effects distinct from its cytotoxic activity at higher doses.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Decitabine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1201129.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 451668.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
चिकित्सा अस्वीकरण

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.