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Fexofenadine Hydrochloride

CHEMBL1200618 Phase 4 अनुमोदित Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
538.1 g/mol
LogP
—
Phase
4

This hydrochloride salt form of fexofenadine is a second-generation antihistamine that controls allergy symptoms including itching, sneezing, and watery eyes without causing significant drowsiness. It is widely used for hay fever, chronic hives, and allergic skin conditions.

आणविक भार

538.1000 g/mol

TPSA

81.00 Ų

चिकित्सीय क्षेत्र

अस्थमा उच्च रक्तचाप एटोपिक डर्मेटाइटिस (एक्जिमा) क्रॉनिक ऑब्सट्रक्टिव पल्मोनरी डिज़ीज़ (COPD) क्रॉनिक किडनी डिज़ीज़ गाउट (गठिया) गैस्ट्रोइसोफेजियल रिफ्लक्स रोग मल्टीपल स्क्लेरोसिस मेजर डिप्रेसिव डिसऑर्डर रुमेटॉइड आर्थराइटिस ल्यूकेमिया सोरायसिस हृदय विफलता

क्रिया का तंत्र

Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

तंत्र

Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.

2D संरचना

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(C)(C(=O)O)c1ccc(C(O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1.Cl

                

                

                
                

                    
InChI

                    
InChI=1S/C32H39NO4.ClH/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27;/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36);1H

                

                

                

                    
                    

                        
Molecular Formula

                        
C32H40ClNO4

                    

                    
                    

                        
HBD / HBA

                        
4 / 5

                    

                    
                    

                        
घूर्णनीय बंधन

                        
10

                    

                    
                    
                    

                        
भारी परमाणु

                        
38

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
अक्सर पूछे जाने वाले प्रश्न

                

                    
                    

                        
                        

                            
This hydrochloride salt form of fexofenadine is a second-generation antihistamine that controls allergy symptoms including itching, sneezing, and watery eyes without causing significant drowsiness. It is widely used for hay fever, chronic hives, and allergic skin conditions.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Fexofenadine Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1200618.
                Open-access bioactivity database.
            
        
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                PubChem — National Center for Biotechnology Information (NCBI).
                CID 63002.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
चिकित्सा अस्वीकरण

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.