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Granisetron Hydrochloride

CHEMBL1237080 Phase 4 अनुमोदित Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
348.9 g/mol
LogP
—
Phase
4

A hydrochloride salt form of granisetron, a 5-HT3 antagonist antiemetic used to prevent and treat nausea and vomiting associated with chemotherapy and postoperative settings. The hydrochloride salt form is used in both oral tablets and injectable preparations. It provides effective antiemetic coverage, particularly for acute chemotherapy-induced nausea occurring within the first 24 hours of treatment.

आणविक भार

348.9000 g/mol

TPSA

50.20 Ų

चिकित्सीय क्षेत्र

अग्नाशय कैंसर ओवेरियन कैंसर कोलोरेक्टल कैंसर थायरॉइड कैंसर दीर्घकालिक दर्द नॉन-स्मॉल सेल लंग कैंसर प्रोस्टेट कैंसर मूत्राशय कैंसर लिम्फोमा ल्यूकेमिया स्तन कैंसर

क्रिया का तंत्र

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

तंत्र

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

2D संरचना

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CN1C2CCCC1CC(NC(=O)c1nn(C)c3ccccc13)C2.Cl

                

                

                
                

                    
InChI

                    
InChI=1S/C18H24N4O.ClH/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17;/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23);1H

                

                

                

                    
                    

                        
Molecular Formula

                        
C18H25ClN4O

                    

                    
                    

                        
HBD / HBA

                        
2 / 3

                    

                    
                    

                        
घूर्णनीय बंधन

                        
2

                    

                    
                    
                    

                        
भारी परमाणु

                        
24

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
अक्सर पूछे जाने वाले प्रश्न

                

                    
                    

                        
                        

                            
A hydrochloride salt form of granisetron, a 5-HT3 antagonist antiemetic used to prevent and treat nausea and vomiting associated with chemotherapy and postoperative settings. The hydrochloride salt form is used in both oral tablets and injectable preparations. It provides effective antiemetic coverage, particularly for acute chemotherapy-induced nausea occurring within the first 24 hours of treatment.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Granisetron Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1237080.
                Open-access bioactivity database.
            
        
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  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 65264.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
चिकित्सा अस्वीकरण

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.