Lumacaftor

CHEMBL2103870 Phase 4 अनुमोदित Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

452.4 g/mol

LogP

4.4

Phase

4

A CFTR corrector used in combination with ivacaftor to treat cystic fibrosis in patients with two copies of the F508del mutation. It helps the misfolded CFTR protein achieve a more stable configuration so it can reach the cell surface.

आणविक भार

452.4000 g/mol

LogP

4.40

TPSA

97.80 Å²

लिपिंस्की RO5

उत्तीर्ण

चिकित्सीय क्षेत्र

टाइप 2 मधुमेह

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D संरचना

SVG PNG

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SMILES

Cc1ccc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)nc1-c1cccc(C(=O)O)c1

InChI

InChI=1S/C24H18F2N2O5/c1-13-5-8-19(27-20(13)14-3-2-4-15(11-14)21(29)30)28-22(31)23(9-10-23)16-6-7-17-18(12-16)33-24(25,26)32-17/h2-8,11-12H,9-10H2,1H3,(H,29,30)(H,27,28,31)

Molecular Formula

C24H18F2N2O5

HBD / HBA

2 / 8

घूर्णनीय बंधन

5

भारी परमाणु

33

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

अक्सर पूछे जाने वाले प्रश्न

A CFTR corrector used in combination with ivacaftor to treat cystic fibrosis in patients with two copies of the F508del mutation. It helps the misfolded CFTR protein achieve a more stable configuration so it can reach the cell surface.

Yes, Lumacaftor is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2103870. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 16678941. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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संरचना

त्वरित डेटा

सूत्र: C24H18F2N2O5
पर्यायवाची: 1

बाहरी लिंक

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चिकित्सा अस्वीकरण

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.