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Plitidepsin

CHEMBL451930 Phase 4 अनुमोदित Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
1110.3 g/mol
LogP
5.7
Phase
4

Plitidepsin is a cyclic depsipeptide of marine origin derived from the tunicate Aplidium albicans that exerts anticancer activity by inhibiting protein synthesis through binding to eukaryotic elongation factor 1A2 (eEF1A2), disrupting the elongation phase of translation. It has demonstrated activity in multiple myeloma, T-cell lymphoma, and leukemia, and has also shown antiviral activity against SARS-CoV-2.

आणविक भार

1110.3000 g/mol

LogP

5.70

TPSA

285.00 Ų

लिपिंस्की RO5

अनुत्तीर्ण

चिकित्सीय क्षेत्र

प्रोस्टेट कैंसर लिम्फोमा ल्यूकेमिया

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D संरचना

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CC[C@H](C)[C@H]1NC(=O)[C@@H](NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H]2CCCN2C(=O)C(C)=O)[C@@H](C)OC(=O)[C@H](Cc2ccc(OC)cc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)C(=O)[C@H](C(C)C)OC(=O)C[C@@H]1O

                

                

                
                

                    
InChI

                    
InChI=1S/C57H87N7O15/c1-15-33(8)46-44(66)29-45(67)79-49(32(6)7)48(68)34(9)50(69)58-39(26-30(2)3)54(73)64-25-17-19-41(64)56(75)62(13)43(28-37-20-22-38(77-14)23-21-37)57(76)78-36(11)47(52(71)59-46)60-51(70)42(27-31(4)5)61(12)55(74)40-18-16-24-63(40)53(72)35(10)65/h20-23,30-34,36,39-44,46-47,49,66H,15-19,24-29H2,1-14H3,(H,58,69)(H,59,71)(H,60,70)/t33-,34-,36+,39-,40-,41-,42+,43-,44-,46+,47-,49-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C57H87N7O15

                    

                    
                    

                        
HBD / HBA

                        
4 / 15

                    

                    
                    

                        
घूर्णनीय बंधन

                        
15

                    

                    
                    
                    

                        
भारी परमाणु

                        
79

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
अक्सर पूछे जाने वाले प्रश्न

                

                    
                    

                        
                        

                            
Plitidepsin is a cyclic depsipeptide of marine origin derived from the tunicate Aplidium albicans that exerts anticancer activity by inhibiting protein synthesis through binding to eukaryotic elongation factor 1A2 (eEF1A2), disrupting the elongation phase of translation. It has demonstrated activity in multiple myeloma, T-cell lymphoma, and leukemia, and has also shown antiviral activity against SARS-CoV-2.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Plitidepsin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL451930.
                Open-access bioactivity database.
            
        
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  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 9812534.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
चिकित्सा अस्वीकरण

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.