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Rofecoxib

CHEMBL122 Phase 4 अनुमोदित Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
314.4 g/mol
LogP
2.3
Phase
4

A selective COX-2 inhibitor that was used to treat pain and inflammation in arthritis and other conditions, withdrawn from the market in 2004 due to an increased risk of heart attack and stroke with long-term use. It represented an important lesson in the cardiovascular risks associated with some anti-inflammatory medications.

आणविक भार

314.4000 g/mol

LogP

2.30

TPSA

68.80 Ų

लिपिंस्की RO5

उत्तीर्ण

चिकित्सीय क्षेत्र

कोलोरेक्टल कैंसर दर्द प्रबंधन दीर्घकालिक दर्द नॉन-स्मॉल सेल लंग कैंसर प्रोस्टेट कैंसर रुमेटॉइड आर्थराइटिस

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D संरचना

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C17H14O4S

                    

                    
                    

                        
HBD / HBA

                        
- / 4

                    

                    
                    

                        
घूर्णनीय बंधन

                        
3

                    

                    
                    
                    

                        
भारी परमाणु

                        
22

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
अक्सर पूछे जाने वाले प्रश्न

                

                    
                    

                        
                        

                            
A selective COX-2 inhibitor that was used to treat pain and inflammation in arthritis and other conditions, withdrawn from the market in 2004 due to an increased risk of heart attack and stroke with long-term use. It represented an important lesson in the cardiovascular risks associated with some anti-inflammatory medications.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Rofecoxib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL122.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5090.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
चिकित्सा अस्वीकरण

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.