💊 दवाएँ A-Z 🧬 लक्ष्य 🛠 उपकरण 📚 मार्गदर्शिकाएँ
सभी दवाएँ दवा वर्ग चिकित्सीय क्षेत्र दुष्प्रभाव
मार्गदर्शिकाएँ शब्दकोश समयरेखा
तुलनाएँ दवाओं की यात्राएँ दवा परिवार
🇺🇸 English 🇰🇷 한국어 🇯🇵 日本語 🇨🇳 中文简体 🇪🇸 Español 🇧🇷 Português 🇮🇳 हिन्दी 🇸🇦 العربية 🇫🇷 Français 🇷🇺 Русский 🇩🇪 Deutsch 🇹🇷 Türkçe 🇻🇳 Tiếng Việt 🇮🇩 Bahasa Indonesia 🇹🇭 ไทย

Tacrine

CHEMBL95 Phase 4 अनुमोदित Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
198.3 g/mol
LogP
2.7
Phase
4

Tacrine (tetrahydroaminoacridine, THA) is a first-generation reversible acetylcholinesterase inhibitor used historically for symptomatic treatment of mild-to-moderate Alzheimer's disease, acting by inhibiting both acetylcholinesterase (AChE) and butyrylcholinesterase to increase acetylcholine levels in cholinergic synapses in the cortex and hippocampus. It also has additional activities including NMDA receptor antagonism, potassium channel blockade, and monoamine oxidase inhibition. Due to high hepatotoxicity risk and the availability of better-tolerated cholinesterase inhibitors, it has been largely discontinued.

आणविक भार

198.2600 g/mol

LogP

2.70

TPSA

38.90 Ų

लिपिंस्की RO5

उत्तीर्ण

चिकित्सीय क्षेत्र

अल्ज़ाइमर रोग इंफ्लेमेटरी बाउल डिज़ीज़ ऑप्थल्मोलॉजी (नेत्र विज्ञान) क्रॉनिक ऑब्सट्रक्टिव पल्मोनरी डिज़ीज़ (COPD) क्रॉनिक किडनी डिज़ीज़ गैस्ट्रोइसोफेजियल रिफ्लक्स रोग टाइप 2 मधुमेह नॉन-अल्कोहलिक फैटी लिवर डिज़ीज़ पार्किंसन रोग श्वसन रोग संक्रामक रोग हाइपरलिपिडेमिया हृदय-संवहनी रोग

क्रिया का तंत्र

Inhibits acetylcholinesterase, the enzyme that hydrolyzes acetylcholine in the synaptic cleft. This increases acetylcholine availability at cholinergic synapses, enhancing cholinergic neurotransmission.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

तंत्र

Inhibits acetylcholinesterase, the enzyme that hydrolyzes acetylcholine in the synaptic cleft. This increases acetylcholine availability at cholinergic synapses, enhancing cholinergic neurotransmission.

2D संरचना

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
Nc1c2c(nc3ccccc13)CCCC2

                

                

                
                

                    
InChI

                    
InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)

                

                

                

                    
                    

                        
Molecular Formula

                        
C13H14N2

                    

                    
                    

                        
HBD / HBA

                        
1 / 2

                    

                    
                    

                        
घूर्णनीय बंधन

                        
0

                    

                    
                    
                    

                        
भारी परमाणु

                        
15

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
अक्सर पूछे जाने वाले प्रश्न

                

                    
                    

                        
                        

                            
Tacrine (tetrahydroaminoacridine, THA) is a first-generation reversible acetylcholinesterase inhibitor used historically for symptomatic treatment of mild-to-moderate Alzheimer's disease, acting by inhibiting both acetylcholinesterase (AChE) and butyrylcholinesterase to increase acetylcholine levels in cholinergic synapses in the cortex and hippocampus. It also has additional activities including NMDA receptor antagonism, potassium channel blockade, and monoamine oxidase inhibition. Due to high hepatotoxicity risk and the availability of better-tolerated cholinesterase inhibitors, it has been largely discontinued.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits acetylcholinesterase, the enzyme that hydrolyzes acetylcholine in the synaptic cleft. This increases acetylcholine availability at cholinergic synapses, enhancing cholinergic neurotransmission.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Tacrine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL95.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 1935.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
चिकित्सा अस्वीकरण

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.