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Thiothixene

CHEMBL1201 Phase 4 अनुमोदित Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
443.6 g/mol
LogP
3.8
Phase
4

Thiothixene is a thioxanthene typical antipsychotic that blocks dopamine D2 receptors in the mesolimbic and mesocortical pathways, reducing positive symptoms of psychosis in schizophrenia and related conditions. It also has some affinity for alpha-adrenergic and histamine H1 receptors, contributing to orthostatic hypotension and sedation. Its high potency D2 blockade is associated with a higher risk of extrapyramidal side effects compared to lower-potency antipsychotics.

आणविक भार

443.6000 g/mol

LogP

3.80

TPSA

77.50 Ų

लिपिंस्की RO5

उत्तीर्ण

चिकित्सीय क्षेत्र

बाइपोलर डिसऑर्डर मोटापा सिज़ोफ्रेनिया स्ट्रोक

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D संरचना

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CN1CCN(CC/C=C2/c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1

                

                

                
                

                    
InChI

                    
InChI=1S/C23H29N3O2S2/c1-24(2)30(27,28)18-10-11-23-21(17-18)19(20-7-4-5-9-22(20)29-23)8-6-12-26-15-13-25(3)14-16-26/h4-5,7-11,17H,6,12-16H2,1-3H3/b19-8-

                

                

                

                    
                    

                        
Molecular Formula

                        
C23H29N3O2S2

                    

                    
                    

                        
HBD / HBA

                        
- / 6

                    

                    
                    

                        
घूर्णनीय बंधन

                        
5

                    

                    
                    
                    

                        
भारी परमाणु

                        
30

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
अक्सर पूछे जाने वाले प्रश्न

                

                    
                    

                        
                        

                            
Thiothixene is a thioxanthene typical antipsychotic that blocks dopamine D2 receptors in the mesolimbic and mesocortical pathways, reducing positive symptoms of psychosis in schizophrenia and related conditions. It also has some affinity for alpha-adrenergic and histamine H1 receptors, contributing to orthostatic hypotension and sedation. Its high potency D2 blockade is associated with a higher risk of extrapyramidal side effects compared to lower-potency antipsychotics.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Thiothixene is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1201.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 941651.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
चिकित्सा अस्वीकरण

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.