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Thonzonium

CHEMBL1201322 Phase 4 अनुमोदित Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
511.8 g/mol
LogP
9.9
Phase
4

Thonzonium is a quaternary ammonium compound with surfactant and antimicrobial properties that acts as a penetration enhancer by reducing surface tension and disrupting microbial membranes, facilitating penetration of co-administered antimicrobial agents into ear canal tissues. It is used as an excipient/adjuvant in otic combination preparations containing corticosteroids and antibiotics for otitis externa. Its ability to disperse coagulated or necrotic debris in the ear canal enhances drug contact with infected tissue.

आणविक भार

511.8000 g/mol

LogP

9.90

TPSA

38.30 Ų

लिपिंस्की RO5

अनुत्तीर्ण

क्रिया का तंत्र

Reduces surface tension at the air-liquid interface in the pulmonary alveoli, preventing alveolar collapse during expiration and improving lung compliance and gas exchange.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

तंत्र

Reduces surface tension at the air-liquid interface in the pulmonary alveoli, preventing alveolar collapse during expiration and improving lung compliance and gas exchange.

2D संरचना

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CCCCCCCCCCCCCCCC[N+](C)(C)CCN(Cc1ccc(OC)cc1)c1ncccn1

                

                

                
                

                    
InChI

                    
InChI=1S/C32H55N4O/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-27-36(2,3)28-26-35(32-33-24-19-25-34-32)29-30-20-22-31(37-4)23-21-30/h19-25H,5-18,26-29H2,1-4H3/q+1

                

                

                

                    
                    

                        
Molecular Formula

                        
C32H55N4O+

                    

                    
                    

                        
HBD / HBA

                        
- / 4

                    

                    
                    

                        
घूर्णनीय बंधन

                        
22

                    

                    
                    
                    

                        
भारी परमाणु

                        
37

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
अक्सर पूछे जाने वाले प्रश्न

                

                    
                    

                        
                        

                            
Thonzonium is a quaternary ammonium compound with surfactant and antimicrobial properties that acts as a penetration enhancer by reducing surface tension and disrupting microbial membranes, facilitating penetration of co-administered antimicrobial agents into ear canal tissues. It is used as an excipient/adjuvant in otic combination preparations containing corticosteroids and antibiotics for otitis externa. Its ability to disperse coagulated or necrotic debris in the ear canal enhances drug contact with infected tissue.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Reduces surface tension at the air-liquid interface in the pulmonary alveoli, preventing alveolar collapse during expiration and improving lung compliance and gas exchange.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Thonzonium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
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                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1201322.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5456.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
चिकित्सा अस्वीकरण

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.