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Tolvaptan

CHEMBL344159 Phase 4 अनुमोदित Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
448.9 g/mol
LogP
4.8
Phase
4

Tolvaptan is a selective vasopressin V2 receptor antagonist (vaptans class) that blocks the antidiuretic action of arginine vasopressin (AVP) in the renal collecting duct, preventing water reabsorption and promoting free water excretion (aquaresis) without significant sodium or potassium loss. It is approved for hyponatremia in syndrome of inappropriate ADH secretion (SIADH), congestive heart failure, and cirrhosis, and for slowing kidney cyst growth in autosomal dominant polycystic kidney disease (ADPKD). Its aquaretic mechanism corrects hyponatremia and reduces cyst expansion without the electrolyte disturbances of conventional diuretics.

आणविक भार

448.9000 g/mol

LogP

4.80

TPSA

69.60 Ų

लिपिंस्की RO5

उत्तीर्ण

चिकित्सीय क्षेत्र

उच्च रक्तचाप क्रॉनिक किडनी डिज़ीज़ हृदय विफलता हृदय-संवहनी रोग

क्रिया का तंत्र

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

तंत्र

Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

2D संरचना

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(O)c3cc(Cl)ccc32)c(C)c1

                

                

                
                

                    
InChI

                    
InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)

                

                

                

                    
                    

                        
Molecular Formula

                        
C26H25ClN2O3

                    

                    
                    

                        
HBD / HBA

                        
2 / 3

                    

                    
                    

                        
घूर्णनीय बंधन

                        
3

                    

                    
                    
                    

                        
भारी परमाणु

                        
32

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
अक्सर पूछे जाने वाले प्रश्न

                

                    
                    

                        
                        

                            
Tolvaptan is a selective vasopressin V2 receptor antagonist (vaptans class) that blocks the antidiuretic action of arginine vasopressin (AVP) in the renal collecting duct, preventing water reabsorption and promoting free water excretion (aquaresis) without significant sodium or potassium loss. It is approved for hyponatremia in syndrome of inappropriate ADH secretion (SIADH), congestive heart failure, and cirrhosis, and for slowing kidney cyst growth in autosomal dominant polycystic kidney disease (ADPKD). Its aquaretic mechanism corrects hyponatremia and reduces cyst expansion without the …

                        

                    

                    

                    

                    
                    

                        
                        

                            
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Tolvaptan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL344159.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 216237.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
चिकित्सा अस्वीकरण

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.