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Valdecoxib

CHEMBL865 Phase 4 अनुमोदित Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
314.4 g/mol
LogP
2.6
Phase
4

Valdecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor that blocks prostaglandin synthesis at inflammatory sites while sparing COX-1-mediated gastric and platelet protection, providing analgesic and anti-inflammatory effects with reduced gastrointestinal side effects compared to non-selective NSAIDs. It was approved for osteoarthritis, rheumatoid arthritis, primary dysmenorrhea, and acute pain management. It was withdrawn from the market due to increased cardiovascular risks and severe skin reactions (Stevens-Johnson syndrome).

आणविक भार

314.4000 g/mol

LogP

2.60

TPSA

94.60 Ų

लिपिंस्की RO5

उत्तीर्ण

चिकित्सीय क्षेत्र

दर्द प्रबंधन दीर्घकालिक दर्द

Pharmacokinetics (PK)

Pharmacodynamics (PD)

2D संरचना

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C16H14N2O3S/c1-11-15(12-7-9-14(10-8-12)22(17,19)20)16(18-21-11)13-5-3-2-4-6-13/h2-10H,1H3,(H2,17,19,20)

                

                

                

                    
                    

                        
Molecular Formula

                        
C16H14N2O3S

                    

                    
                    

                        
HBD / HBA

                        
1 / 5

                    

                    
                    

                        
घूर्णनीय बंधन

                        
3

                    

                    
                    
                    

                        
भारी परमाणु

                        
22

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
अक्सर पूछे जाने वाले प्रश्न

                

                    
                    

                        
                        

                            
Valdecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor that blocks prostaglandin synthesis at inflammatory sites while sparing COX-1-mediated gastric and platelet protection, providing analgesic and anti-inflammatory effects with reduced gastrointestinal side effects compared to non-selective NSAIDs. It was approved for osteoarthritis, rheumatoid arthritis, primary dysmenorrhea, and acute pain management. It was withdrawn from the market due to increased cardiovascular risks and severe skin reactions (Stevens-Johnson syndrome).

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Valdecoxib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL865.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 119607.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
चिकित्सा अस्वीकरण

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.