Major
Established
विवरण
Alprazolam combined with morphine carries an FDA boxed warning for serious risk of respiratory depression, sedation, coma, and death.
तंत्र
Alprazolam potentiates GABA-A inhibitory tone; morphine reduces brainstem respiratory drive via mu-opioid receptors — both pathways converge on CNS and respiratory depression.
नैदानिक महत्व
Large database studies confirm excess mortality with concomitant benzodiazepine and opioid prescriptions.
प्रबंधन
Prescribe concurrent opioids and benzodiazepines only when alternatives are inadequate; coprescribe naloxone.