विवरण

Azithromycin and quetiapine both prolong the QT interval via hERG blockade; concurrent use significantly increases the risk of life-threatening arrhythmias.

तंत्र

Additive hERG (IKr) potassium channel blockade prolongs ventricular repolarization; azithromycin also inhibits CYP3A4 modestly, potentially increasing quetiapine exposure.

नैदानिक महत्व

Multiple case reports and pharmacovigilance data document torsades de pointes with this combination.

प्रबंधन

Avoid combination; use alternative antibiotics (e.g., amoxicillin) when possible; if unavoidable, obtain ECG and correct electrolytes.

चिकित्सा अस्वीकरण

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.