Minor
Suspected
विवरण
Fluconazole inhibits CYP3A4, which contributes to finasteride metabolism; co-administration may modestly increase finasteride plasma concentrations, though the clinical significance is generally low.
तंत्र
Finasteride is metabolised primarily by CYP3A4; fluconazole's CYP3A4 inhibition reduces finasteride clearance, potentially increasing AUC by 10–20%; however, finasteride has a wide therapeutic index.
नैदानिक महत्व
No clinically significant adverse effects reported at usual doses; theoretical modest increase in finasteride side effects (sexual dysfunction) is unlikely to be detectable.
प्रबंधन
No dose adjustment is required; monitor for increased finasteride side effects (decreased libido, erectile dysfunction) during prolonged fluconazole courses.