विवरण

Fluconazole inhibits the metabolism of ondansetron and both drugs prolong the QT interval, creating a compounded arrhythmia risk.

तंत्र

Fluconazole inhibits CYP3A4 and CYP2C9, reducing ondansetron clearance and increasing its plasma concentrations; both drugs independently block hERG channels.

नैदानिक महत्व

The combination can markedly increase ondansetron exposure and QTc prolongation; cases of torsades de pointes have been documented.

प्रबंधन

Avoid combination or use the lowest effective ondansetron dose with ECG monitoring; correct hypokalemia before initiating.

चिकित्सा अस्वीकरण

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.