Major Probable

विवरण

Hydroxychloroquine and ondansetron both prolong cardiac repolarization via hERG blockade; concurrent use substantially elevates arrhythmia risk.

तंत्र

Additive IKr (hERG) blockade prolongs QTc in a dose-dependent manner; hydroxychloroquine may also affect sodium and calcium currents.

नैदानिक महत्व

Both drugs carry independent QT prolongation warnings; combination has been linked to torsades de pointes in case reports.

प्रबंधन

Avoid concurrent use; if antiemesis is needed during hydroxychloroquine therapy, choose a non-QT-prolonging agent such as metoclopramide (with its own caveats) or a corticosteroid-based antiemetic strategy.

चिकित्सा अस्वीकरण

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.