Moderate
Established
विवरण
Rosuvastatin increases warfarin plasma concentrations through inhibition of CYP2C9, potentially leading to supratherapeutic INR values.
तंत्र
Rosuvastatin inhibits CYP2C9, the principal enzyme for S-warfarin metabolism, resulting in reduced clearance and elevated warfarin levels.
नैदानिक महत्व
INR increases of approximately 10–20% have been observed in pharmacokinetic studies; clinically significant bleeding has been reported.
प्रबंधन
Monitor INR when initiating or adjusting rosuvastatin dose; the FDA label specifically warns about this interaction.