Dulaglutide vs Sitagliptin

## Dulaglutide vs Sitagliptin: Overview

This comparison examines the pharmacological differences between **Dulaglutide** and **Sitagliptin**.

## Mechanism of Action

**Dulaglutide**: GLP-1 receptor agonist fused to Fc fragment; enhances glucose-dependent insulin secretion.

**Sitagliptin**: DPP-4 inhibitor increasing incretin levels.

## Pharmacokinetics

**Half-life**: Dulaglutide — 5 days; Sitagliptin — 12.4 hours.

## Chemical Properties

**Molecular Formula**: Dulaglutide — N/A; Sitagliptin — C16H15F6N5O.

**Molecular Weight**: Dulaglutide — N/A; Sitagliptin — 407.3140 g/mol.

**Type**: Dulaglutide — Protein; Sitagliptin — Small molecule.