Gefitinib vs Methotrexate

## Gefitinib vs Methotrexate: Overview

This comparison examines the pharmacological differences between **Gefitinib** and **Methotrexate**.

## Mechanism of Action

**Gefitinib**: Selective reversible inhibitor of EGFR tyrosine kinase.

**Methotrexate**: Dihydrofolate reductase inhibitor.

## Pharmacokinetics

**Half-life**: Gefitinib — 48 hours; Methotrexate — 3-10 hours.

## Chemical Properties

**Molecular Formula**: Gefitinib — C22H24ClFN4O3; Methotrexate — C20H22N8O5.

**Molecular Weight**: Gefitinib — 446.9000 g/mol; Methotrexate — 454.4400 g/mol.

**Type**: Gefitinib — Small molecule; Methotrexate — Small molecule.