Hydrochlorothiazide vs Zolpidem

## Hydrochlorothiazide vs Zolpidem: Overview

This comparison examines the pharmacological differences between **Hydrochlorothiazide** and **Zolpidem**.

## Mechanism of Action

**Hydrochlorothiazide**: Inhibits Na+/Cl- cotransporter in distal convoluted tubule.

**Zolpidem**: Selective GABA-A receptor alpha-1 subunit agonist.

## Pharmacokinetics

**Half-life**: Hydrochlorothiazide — 6-15 hours; Zolpidem — 2.5 hours.

## Chemical Properties

**Molecular Formula**: Hydrochlorothiazide — C7H8ClN3O4S2; Zolpidem — C19H21N3O.

**Molecular Weight**: Hydrochlorothiazide — 297.7400 g/mol; Zolpidem — 307.3950 g/mol.

**Type**: Hydrochlorothiazide — Small molecule; Zolpidem — Small molecule.