Metformin vs Sitagliptin

## Metformin vs Sitagliptin: Overview

This comparison examines the pharmacological differences between **Metformin** and **Sitagliptin**.

## Mechanism of Action

**Metformin**: Activates AMP-activated protein kinase, decreasing hepatic glucose production.

**Sitagliptin**: DPP-4 inhibitor increasing incretin levels.

## Pharmacokinetics

**Half-life**: Metformin — 4-9 hours; Sitagliptin — 12.4 hours.

## Chemical Properties

**Molecular Formula**: Metformin — C4H11N5; Sitagliptin — C16H15F6N5O.

**Molecular Weight**: Metformin — 129.1640 g/mol; Sitagliptin — 407.3140 g/mol.

**Type**: Metformin — Small molecule; Sitagliptin — Small molecule.