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Amiloride

CHEMBL945 Phase 4 Disetujui Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
229.6 g/mol
LogP
-0.7
Phase
4

A potassium-sparing diuretic that blocks sodium channels in the kidney tubules, reducing sodium reabsorption and water retention without causing the potassium loss associated with most other diuretics. It is used to treat high blood pressure and fluid overload, often combined with potassium-wasting diuretics to maintain normal potassium levels.

Berat Molekul

229,6300 g/mol

LogP

-0,70

TPSA

159,00 Ų

Lipinski RO5

Lulus

Area Terapeutik

Migraine Bipolar Disorder Gastroesophageal Reflux Disease Multiple Sclerosis Chronic Kidney Disease Obesity Type 2 Diabetes Hypertension Breast Cancer Heart Failure Cardiovascular Disease

Mekanisme Kerja

Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Mekanisme

Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.

Struktur 2D

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
N=C(N)NC(=O)c1nc(Cl)c(N)nc1N

                

                

                
                

                    
InChI

                    
InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)

                

                

                

                    
                    

                        
Molecular Formula

                        
C6H8ClN7O

                    

                    
                    

                        
HBD / HBA

                        
4 / 5

                    

                    
                    

                        
Ikatan yang Dapat Dirotasi

                        
1

                    

                    
                    
                    

                        
Atom Berat

                        
15

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
Pertanyaan yang Sering Diajukan

                

                    
                    

                        
                        

                            
A potassium-sparing diuretic that blocks sodium channels in the kidney tubules, reducing sodium reabsorption and water retention without causing the potassium loss associated with most other diuretics. It is used to treat high blood pressure and fluid overload, often combined with potassium-wasting diuretics to maintain normal potassium levels.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Amiloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL945.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 16231.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
Penyangkalan Medis

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.