Amitriptyline

CHEMBL629 Phase 4 Disetujui Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

277.4 g/mol

LogP

5.0

Phase

4

A tricyclic antidepressant that raises levels of serotonin and norepinephrine in the brain by preventing their reabsorption into nerve cells. Beyond depression, it is widely used off-label for chronic pain, nerve pain, and sleep disturbances.

Berat Molekul

277,4000 g/mol

LogP

5,00

TPSA

3,20 Å²

Lipinski RO5

Lulus

Area Terapeutik

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Pain Management Non-Small Cell Lung Cancer Parkinson's Disease Epilepsy Migraine Schizophrenia Generalized Anxiety Disorder Insomnia Gastroesophageal Reflux Disease Inflammatory Bowel Disease Multiple Sclerosis Stroke Lymphoma Major Depressive Disorder Breast Cancer Chronic Pain HIV/AIDS Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Struktur 2D

SVG PNG

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SMILES

CN(C)CCC=C1c2ccccc2CCc2ccccc21

InChI

InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3

Molecular Formula

C20H23N

HBD / HBA

- / 1

Ikatan yang Dapat Dirotasi

3

Atom Berat

21

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

Pertanyaan yang Sering Diajukan

A tricyclic antidepressant that raises levels of serotonin and norepinephrine in the brain by preventing their reabsorption into nerve cells. Beyond depression, it is widely used off-label for chronic pain, nerve pain, and sleep disturbances.

Yes, Amitriptyline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL629. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 2160. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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Amitriptyline di PillFYI

Struktur

Data Cepat

Rumus: C20H23N
Sinonim: 4

Tautan Eksternal

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Penyangkalan Medis

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.