Avacopan
A selective complement C5a receptor antagonist taken by mouth that dampens the inflammatory response driven by the complement system in certain autoimmune vasculitides such as ANCA-associated vasculitis. It allows dose reduction of steroids while maintaining disease control.
Berat Molekul
581,6000 g/mol
LogP
7,20
TPSA
61,40 Ų
Lipinski RO5
Gagal
Area Terapeutik
Mekanisme Kerja
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Struktur 2D
Cite this structure
Embed this structure
SMILES
Cc1ccc(NC(=O)[C@H]2CCCN(C(=O)c3c(C)cccc3F)[C@H]2c2ccc(NC3CCCC3)cc2)cc1C(F)(F)F
InChI
InChI=1S/C33H35F4N3O2/c1-20-12-15-25(19-27(20)33(35,36)37)39-31(41)26-10-6-18-40(32(42)29-21(2)7-5-11-28(29)34)30(26)22-13-16-24(17-14-22)38-23-8-3-4-9-23/h5,7,11-17,19,23,26,30,38H,3-4,6,8-10,18H2,1-2H3,(H,39,41)/t26-,30-/m0/s1
Molecular Formula
C33H35F4N3O2
HBD / HBA
2 / 7
Ikatan yang Dapat Dirotasi
6
Atom Berat
42
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Pertanyaan yang Sering Diajukan
A selective complement C5a receptor antagonist taken by mouth that dampens the inflammatory response driven by the complement system in certain autoimmune vasculitides such as ANCA-associated vasculitis. It allows dose reduction of steroids while maintaining disease control.
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Yes, Avacopan is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3989871. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 49841217. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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