Baricitinib
A JAK1/JAK2 inhibitor that blocks the intracellular signaling pathways that drive inflammation in conditions such as rheumatoid arthritis and atopic dermatitis. It is taken by mouth once daily.
Berat Molekul
371,4170 g/mol
LogP
-0,50
TPSA
129,00 Ų
Lipinski RO5
Lulus
Area Terapeutik
Kelas Obat
Mekanisme Kerja
Selective JAK1 and JAK2 inhibitor blocking cytokine signaling involved in inflammation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selective JAK1 and JAK2 inhibitor blocking cytokine signaling involved in inflammation.
Struktur 2D
Cite this structure
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SMILES
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3ncnc4[nH]ccc34)cn2)C1
InChI
InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)
Molecular Formula
C16H17N7O2S
HBD / HBA
1 / 7
Ikatan yang Dapat Dirotasi
5
Atom Berat
26
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Pertanyaan yang Sering Diajukan
A JAK1/JAK2 inhibitor that blocks the intracellular signaling pathways that drive inflammation in conditions such as rheumatoid arthritis and atopic dermatitis. It is taken by mouth once daily.
Selective JAK1 and JAK2 inhibitor blocking cytokine signaling involved in inflammation.
Key pharmacokinetic parameters for Baricitinib: Half-life: 12 hours.
Yes, Baricitinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
Related Drugs
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2105759. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 44205240. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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