Bortezomib D-Mannitol
A formulation of bortezomib, a proteasome inhibitor used to treat multiple myeloma and certain types of mantle cell lymphoma, lyophilized with d-mannitol for stability. It disrupts protein degradation pathways in cancer cells, triggering cell death. Side effects include peripheral neuropathy, low blood counts, and fatigue.
Berat Molekul
530,4000 g/mol
TPSA
183,00 Ų
Mekanisme Kerja
Inhibits the 26S proteasome, blocking the ubiquitin-proteasome pathway of intracellular protein degradation. This leads to accumulation of pro-apoptotic proteins and induces cell death in rapidly dividing cancer cells.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits the 26S proteasome, blocking the ubiquitin-proteasome pathway of intracellular protein degradation. This leads to accumulation of pro-apoptotic proteins and induces cell death in rapidly dividing cancer cells.
Struktur 2D
Cite this structure
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SMILES
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B1O[C@H]([C@H](O)CO)[C@@H]([C@H](O)CO)O1
InChI
InChI=1S/C25H35BN4O8/c1-15(2)10-21(26-37-22(19(33)13-31)23(38-26)20(34)14-32)30-24(35)17(11-16-6-4-3-5-7-16)29-25(36)18-12-27-8-9-28-18/h3-9,12,15,17,19-23,31-34H,10-11,13-14H2,1-2H3,(H,29,36)(H,30,35)/t17-,19+,20+,21-,22+,23+/m0/s1
Molecular Formula
C25H35BN4O8
HBD / HBA
6 / 10
Ikatan yang Dapat Dirotasi
13
Atom Berat
38
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Pertanyaan yang Sering Diajukan
A formulation of bortezomib, a proteasome inhibitor used to treat multiple myeloma and certain types of mantle cell lymphoma, lyophilized with d-mannitol for stability. It disrupts protein degradation pathways in cancer cells, triggering cell death. Side effects include peripheral neuropathy, low blood counts, and fatigue.
Inhibits the 26S proteasome, blocking the ubiquitin-proteasome pathway of intracellular protein degradation. This leads to accumulation of pro-apoptotic proteins and induces cell death in rapidly dividing cancer cells.
Yes, Bortezomib D-Mannitol is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL5315122. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 12990536. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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