Brompheniramine Maleate
The maleate salt of brompheniramine, used in over-the-counter allergy and cold preparations to relieve runny nose, sneezing, and itchy eyes. Like other first-generation antihistamines, it crosses the blood-brain barrier and can cause drowsiness. It is often combined with decongestants or cough suppressants.
Berat Molekul
435,3000 g/mol
TPSA
90,70 Ų
Mekanisme Kerja
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Struktur 2D
Cite this structure
Embed this structure
SMILES
CN(C)CCC(c1ccc(Br)cc1)c1ccccn1.O=C(O)/C=C\C(=O)O
InChI
InChI=1S/C16H19BrN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
Molecular Formula
C20H23BrN2O4
HBD / HBA
2 / 6
Ikatan yang Dapat Dirotasi
7
Atom Berat
27
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
Pertanyaan yang Sering Diajukan
The maleate salt of brompheniramine, used in over-the-counter allergy and cold preparations to relieve runny nose, sneezing, and itchy eyes. Like other first-generation antihistamines, it crosses the blood-brain barrier and can cause drowsiness. It is often combined with decongestants or cough suppressants.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Brompheniramine Maleate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200961. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 5281067. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Embed This Widget
Add the script tag and a data attribute to embed this widget.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<div data-drugfyi="drug" data-slug="brompheniramine-maleate"></div>Embed via iframe for maximum compatibility.
<iframe src="https://drugfyi.com/iframe/drug/brompheniramine-maleate/" width="420" height="400" frameborder="0" style="border:0;border-radius:10px;max-width:100%" loading="lazy"></iframe>Paste this URL in WordPress, Medium, or any oEmbed-compatible platform.
https://drugfyi.com/drug/brompheniramine-maleate/Add a dynamic SVG badge to your README or docs.
[](https://drugfyi.com/drug/brompheniramine-maleate/)Use the native HTML custom element.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<drugfyi-drug slug="brompheniramine-maleate"></drugfyi-drug>